How certain brain receptors interact and affect signaling
Official title: Impact of Metabotropic Glutamate Receptor Heteromerization on Signaling and Pharmacology
Funded at New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · NIH-11080386 · Data updated 2026-11-12
This study is looking at how certain brain receptors work together in pairs and how this affects their response to different medications, which could help create better treatments for addiction and other brain disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 2, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $603,392 |
| NIH project number | 5R01NS132060-03 |
| Project ID | NIH-11080386 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from addiction or related neurological disorders.
✕Less likely to help
Patients with conditions unrelated to glutamate signaling or those not experiencing addiction may not benefit from this research.
What this research studies
This research investigates the interactions between metabotropic glutamate receptors in the brain, focusing on how these receptors can form unique pairs, known as heterodimers, that behave differently than when they exist alone. By using a specialized technique called CODA-RET, the researchers aim to understand how these receptor pairs respond to various drugs, which could lead to more targeted treatments for conditions like addiction. The study will explore the specific pharmacological effects of different compounds on these receptor interactions, potentially revealing new therapeutic strategies for brain disorders.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted treatments for addiction and other neurological conditions.
How similar studies have gone: Previous research has shown promise in understanding receptor interactions, but this specific approach using CODA-RET is relatively novel.
Where this research is happening
-
New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
New York, United States Active
Researchers
- Principal investigator: Javitch, Jonathan a — New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
- Study coordinator: Javitch, Jonathan a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.