How certain brain cells help protect the brain after injury
Official title: The neuroprotective role of proliferative reactive astrocytes in the hippocampus, synapse preservation and regeneration following traumatic brain injury
Funded at Indiana University Indianapolis · NIH-10928420 · Data updated 2026-11-12
This study is looking at how certain brain cells called reactive astrocytes help protect the brain after a traumatic brain injury, with the hope of finding new ways to improve recovery and memory for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $554,750 |
| NIH project number | 1R56NS131465-01A1 |
| Project ID | NIH-10928420 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a traumatic brain injury and are seeking potential new treatment options.
✕Less likely to help
Patients with non-traumatic brain injuries or those who do not have significant neurological deficits may not benefit from this research.
What this research studies
This research investigates the role of reactive astrocytes, a type of brain cell, in protecting the brain following traumatic brain injury (TBI). The study aims to understand how these cells proliferate and their effects on preserving and regenerating synapses in the hippocampus, a critical area for memory and learning. By examining the signaling pathways involved, particularly the platelet-derived growth factor receptor alpha (PDGFRα), the research seeks to identify potential therapeutic targets that could improve recovery after brain injuries. Patients may benefit from insights gained that could lead to new treatments for TBI.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance recovery and functional outcomes for patients with traumatic brain injuries.
How similar studies have gone: Previous research has shown promise in understanding the role of astrocytes in brain injury recovery, indicating that this approach could yield valuable insights.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Gao, Xiang — Indiana University Indianapolis
- Study coordinator: Gao, Xiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.