How certain brain cells affect white matter changes in vascular dementia
Oligodendrocyte Precursor Cells Regulate White Matter Remodeling in Vascular Cognitive Impairment and Dementia
This study is looking at how certain brain cells called oligodendrocyte precursor cells are involved in a type of dementia that affects thinking skills, especially as we age, to find ways to help improve brain health for people dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10650804 on NIH RePORTER |
What this research studies
This research investigates the role of oligodendrocyte precursor cells in the development of subcortical ischemic vascular dementia (SIVD), a common form of vascular cognitive impairment. The study aims to understand how aging impacts the pathology of SIVD, particularly focusing on white matter degeneration and its link to cognitive decline. By exploring the mechanisms of oligodendrocyte differentiation and myelination, the research seeks to identify potential therapeutic targets for improving brain function in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing cognitive decline associated with vascular dementia, particularly those with subcortical ischemic vascular dementia.
Not a fit: Patients with cognitive impairments not related to vascular issues or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance white matter health and cognitive function in patients with vascular dementia.
How similar studies have performed: While research on oligodendrocyte mechanisms is limited, similar studies in other forms of dementia have shown promising results, indicating potential for success in this area.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Arai, Ken — Massachusetts General Hospital
- Study coordinator: Arai, Ken
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.