How certain brain cells affect blood flow and imaging of brain function
Inhibitory Neuron Sub-populations and Their Influence on Hemodynamic Imaging
This study is looking at how certain brain cells affect blood flow and brain imaging signals, which could help us understand why some brain scans don’t always show what’s really happening in the brains of people with neurological disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11012845 on NIH RePORTER |
What this research studies
This research investigates how different types of inhibitory neurons in the brain influence local blood flow and the signals used in brain imaging. By using specialized mouse models, the study aims to understand the complex interactions between neuronal activity and blood supply during both active tasks and resting states. The findings could help clarify why some imaging studies may not accurately reflect brain activity, especially in individuals with neurological disorders. Ultimately, this research seeks to bridge the gap between animal models and human brain function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological disorders that may involve dysfunction of inhibitory neurons.
Not a fit: Patients without neurological disorders or those who do not have issues related to brain function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved brain imaging techniques and better understanding of neurological disorders.
How similar studies have performed: Other research has shown promising results in understanding the role of neuronal populations in brain function, making this approach both relevant and potentially impactful.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Vazquez, Alberto L — University of Pittsburgh at Pittsburgh
- Study coordinator: Vazquez, Alberto L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.