How certain bacteria may help reduce inflammation in gum disease
Microbial sphingolipids and suppression of host inflammation in periodontal disease
This study is looking at how certain substances made by bacteria in your mouth can help calm down the inflammation that causes gum disease, with the hope of finding new ways to treat it and improve your oral health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10876433 on NIH RePORTER |
What this research studies
This research investigates the role of microbial sphingolipids produced by bacteria in the Bacteroidetes phylum, particularly Porphyromonas gingivalis, in modulating the host's immune response during periodontal disease. The study aims to understand how these bacterial molecules can suppress inflammation, which is a key factor in the progression of gum disease. By examining the mechanisms of immune regulation and the transfer of these sphingolipids to host cells, the research seeks to uncover new insights into the chronic nature of periodontal disease and its treatment. Patients may benefit from findings that could lead to innovative therapies targeting inflammation in gum disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from periodontal disease, particularly those with chronic inflammation.
Not a fit: Patients without periodontal disease or those who do not have a significant inflammatory response may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively manage inflammation in periodontal disease, improving oral health outcomes for patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of microbial interactions in immune regulation, suggesting that this approach may yield valuable insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Gibson, Frank C — University of Florida
- Study coordinator: Gibson, Frank C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.