How certain bacteria affect the harmful effects of Clostridioides difficile
Context-specific modulation of Clostridioides difficile virulence by Vancomycin-resistant Enterococcus faecium
This study is looking at how a type of bacteria called Vancomycin-resistant Enterococcus faecium (VRE) affects another bacteria, Clostridioides difficile (C. difficile), to see if it can help reduce the problems caused by C. difficile infections, especially by understanding how they interact in our gut.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of Ny,binghamton NIH-funded |
| Lab location | 1 site (Binghamton, United States) |
| Project ID | NIH-10629341 on NIH RePORTER |
What this research studies
This research investigates how Vancomycin-resistant Enterococcus faecium (VRE) interacts with Clostridioides difficile (C. difficile) to influence its virulence. The study aims to understand the mechanisms by which VRE can inhibit the growth and sporulation of C. difficile, particularly in relation to different carbon sources in the intestinal environment. By exploring these interactions, the research seeks to identify potential treatments that could mitigate the risks associated with C. difficile infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of or currently experiencing Clostridioides difficile infections.
Not a fit: Patients who do not have Clostridioides difficile infections or are not at risk for such infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the severity of Clostridioides difficile infections.
How similar studies have performed: Other research has shown promising results in understanding bacterial interactions that influence virulence, suggesting that this approach may yield valuable insights.
Where this research is happening
Binghamton, United States
- State University of Ny,binghamton — Binghamton, United States (Active)
Researchers
- Principal investigator: Mckenney, Peter T — State University of Ny,binghamton
- Study coordinator: Mckenney, Peter T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.