How certain air pollutants can lead to cancer development
Metabolic activation of nitroarenes and Nrf2-Keap1
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10976712
This study is looking at how harmful chemicals from car exhaust can affect lung cells and possibly lead to cancer, helping us understand how these pollutants might damage our bodies.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10976712 on ClinicalTrials.gov |
What this research studies
This research investigates how nitroarenes, harmful chemicals found in car exhaust, can activate pathways in the body that may lead to cancer. It focuses on understanding the metabolic processes that convert these pollutants into potentially dangerous substances that can damage DNA and proteins. By studying human lung cells, the researchers aim to uncover the mechanisms by which exposure to these pollutants contributes to cancer development, particularly in the lungs. The study will utilize advanced cell culture techniques to analyze the effects of nitroarenes on cellular functions and genetic expression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals exposed to high levels of air pollution, particularly those living in urban areas with heavy traffic.
Not a fit: Patients who are not exposed to air pollutants or who do not have a history of lung-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for lung cancer related to air pollution.
How similar studies have performed: Previous research has shown that understanding the metabolic activation of carcinogens can lead to significant advancements in cancer prevention and treatment strategies.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PENNING, TREVOR M — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: PENNING, TREVOR M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.