How cellular forces affect chromatin and gene regulation
Official title: The genetic and non-genetic responses of chromatin to force
Funded at Yale University · NIH-11056870 · Data updated 2026-11-12
This study is looking at how the structure and movement inside our cells affect how genes work and stay healthy, focusing on a special part of the cell called the LINC complex, which could help us understand diseases related to changes in our genetic material.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | April 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $376,875 |
| NIH project number | 5R35GM153474-02 |
| Project ID | NIH-11056870 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to epigenetic changes or chromatin dynamics, such as certain cancers or genetic disorders.
✕Less likely to help
Patients with conditions unrelated to chromatin dynamics or epigenetic changes may not benefit from this research.
What this research studies
This research investigates how forces within cells influence chromatin dynamics, gene regulation, and the integrity of the genome. By studying the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex, the research aims to uncover both genetic and non-genetic functions of chromatin. The project will utilize advanced tools and techniques to explore how mechanical forces impact the properties and functions of chromatin, which may have implications for understanding various diseases linked to epigenetic changes.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of gene regulation and potentially inform treatments for diseases associated with epigenetic modifications.
How similar studies have gone: While the specific focus on the mechanical properties of chromatin is relatively novel, previous research has shown success in understanding the role of epigenetics in disease.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: King, Megan C — Yale University
- Study coordinator: King, Megan C
Related research
Other NIH-funded projects on the same topics.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Community Health Worker–Led Hypertension Prevention and Control in Nepal
A community health worker–driven approach in Nepal aims to prevent and control high blood pressure among adults by bringing education and care directly to communities and homes.
-
Community health worker-led hypertension prevention and control in Nepal
A community health worker–led program in Nepal aims to help adults prevent and better control high blood pressure through home visits, education, and ongoing support.
-
Adapting a mobile health tool to boost HIV outcomes for older adults with HIV in Ukraine
A mobile health platform called PositiveLinks would be adapted for older adults with HIV in Ukraine to help them stay engaged in care and improve treatment success.
-
Behavioral and neural links between spoken language sounds and written words in young children
This grant studies how young children learn from listening and reading to improve literacy, by looking at how sound patterns transfer to written language.
-
Understanding how autoimmunity causes myasthenia gravis
This project looks at why the immune system attacks the nerve-muscle connection in myasthenia gravis and how different patient groups are affected.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.