How cellular forces affect chromatin and gene regulation
The genetic and non-genetic responses of chromatin to force
This study is looking at how the structure and movement inside our cells affect how genes work and stay healthy, focusing on a special part of the cell called the LINC complex, which could help us understand diseases related to changes in our genetic material.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11056870 on NIH RePORTER |
What this research studies
This research investigates how forces within cells influence chromatin dynamics, gene regulation, and the integrity of the genome. By studying the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex, the research aims to uncover both genetic and non-genetic functions of chromatin. The project will utilize advanced tools and techniques to explore how mechanical forces impact the properties and functions of chromatin, which may have implications for understanding various diseases linked to epigenetic changes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to epigenetic changes or chromatin dynamics, such as certain cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to chromatin dynamics or epigenetic changes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of gene regulation and potentially inform treatments for diseases associated with epigenetic modifications.
How similar studies have performed: While the specific focus on the mechanical properties of chromatin is relatively novel, previous research has shown success in understanding the role of epigenetics in disease.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: King, Megan C — Yale University
- Study coordinator: King, Megan C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.