How cells work together to shape tissues during development
Mechanisms coordinating cell behaviors within tissues during development
This study looks at how cells work together to move and form tissues during the early stages of development, using fruit flies to learn more about the proteins that help them stick together and move as a group.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10829393 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells coordinate their movements to form functional tissues during embryonic development. By using the fruit fly Drosophila melanogaster as a model organism, the research aims to understand how contractile and adhesive proteins in cells facilitate collective movements and tissue formation. The study employs innovative technologies to control and measure the forces and behaviors of cells, allowing for a detailed analysis of the molecular and mechanical inputs that guide these processes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with congenital anatomical abnormalities or birth defects.
Not a fit: Patients with fully developed tissues and no congenital or developmental disorders may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for congenital defects and other developmental disorders.
How similar studies have performed: Other research has shown success in understanding cell behavior and tissue formation, but this approach may offer novel insights into the specific mechanisms involved.
Where this research is happening
New York, United States
- Columbia Univ New York Morningside — New York, United States (Active)
Researchers
- Principal investigator: Kasza, Karen — Columbia Univ New York Morningside
- Study coordinator: Kasza, Karen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.