How cells work together to shape embryos and organs
The emergence of collective cell behaviors from intercellular interactions
This study looks at how groups of cells work together to move and form important structures in developing embryos and organs, which can help us understand why some birth defects, like spina bifida, happen.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project ID | NIH-11109444 on NIH RePORTER |
What this research studies
This research investigates how groups of cells coordinate their movements to form structures in embryos and organs. It focuses on understanding the molecular mechanisms that enable these collective behaviors, particularly through a pathway known as planar cell polarity (PCP). By studying these processes, the research aims to uncover how disruptions in cell movement can lead to birth defects such as spina bifida. The approach involves detailed analysis of cell interactions and behaviors in biological models, which could provide insights into tissue engineering and developmental biology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of birth defects or those interested in developmental biology.
Not a fit: Patients with conditions unrelated to cell movement or structural birth defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating structural birth defects.
How similar studies have performed: Other research has shown promise in understanding collective cell behaviors, but this specific approach to studying PCP is relatively novel.
Where this research is happening
Princeton, UNITED STATES
- Princeton University — Princeton, United States (Active)
Researchers
- Principal investigator: Devenport, Danelle N — Princeton University
- Study coordinator: Devenport, Danelle N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.