How cells use energy to regrow bone
Cellular metabolism at the crossroads of skeletal regeneration
This project explores how our body's cells use energy to regrow bone, especially after an injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11116867 on NIH RePORTER |
What this research studies
When you get hurt, your body works hard to repair itself, and regrowing bone takes a lot of energy. We want to understand how cells manage this energy and what genes control the process of bone regeneration. By looking at how cells use energy and how certain genes behave, we hope to find new ways to help bones heal better. We are exploring if specific nutrients or gene adjustments can improve bone regrowth.
Who could benefit from this research
Good fit: This foundational work is not directly recruiting patients but aims to help individuals who experience bone injuries or require limb regeneration.
Not a fit: Patients without bone injuries or conditions requiring regeneration would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that help people recover from bone injuries or amputations more effectively.
How similar studies have performed: While the exact metabolic and genetic controls of skeletal regeneration are largely unknown, some preliminary findings suggest that metabolism can be manipulated to influence bone regrowth.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Sammarco, Mimi C — Mayo Clinic Rochester
- Study coordinator: Sammarco, Mimi C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.