How cells surrounding the gut impact aging
Understanding the role of the stromal cell niche in intestinal stem cell aging
This research explores how aging affects the special cells in your gut that help it repair itself, focusing on the surrounding cells that support them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11329187 on NIH RePORTER |
What this research studies
As we age, the ability of our gut to repair itself declines because the special stem cells responsible for this process don't work as well. These crucial stem cells rely on support from neighboring cells, called stromal cells, which create a vital 'niche.' This project is looking at a specific factor, RSPO3, produced by two types of these stromal cells: fibroblasts and lymphatic cells. Researchers have found that these supporting fibroblasts decline significantly with age, and a specific enzyme, Ahcy, plays a key role in this decline. They are exploring ways to reverse this age-related decline in supporting cells, potentially by adjusting how the body processes methionine.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future studies might seek older individuals interested in gut health or the aging process.
Not a fit: Patients seeking immediate treatment for existing conditions would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to keep our intestines healthy as we get older and improve their natural ability to heal and regenerate.
How similar studies have performed: This work builds on existing knowledge about stem cell niches but introduces novel findings about specific cell types and metabolic pathways involved in intestinal aging.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Goto, Norihiro — Weill Medical Coll of Cornell Univ
- Study coordinator: Goto, Norihiro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.