How cells sense and respond to mechanical signals through integrin proteins
Computational models of cell mechanosensing through integrin-based adhesions
This study is looking at how certain proteins in our cells react to physical signals around them, which could help us understand how cells move and behave in conditions like cancer and heart disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10918103 on NIH RePORTER |
What this research studies
This research investigates how integrin proteins, which are crucial for cell adhesion and communication, respond to mechanical signals from their environment. By using advanced computational models, the study aims to uncover the molecular mechanisms that govern these responses and how they influence cell movement. The approach combines molecular dynamics simulations with innovative modeling techniques to explore the conformational changes in integrins that occur under different mechanical conditions. Understanding these processes could lead to new insights into various diseases where cell behavior is affected, such as cancer and cardiovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cell adhesion and signaling, such as certain cancers or cardiovascular diseases.
Not a fit: Patients with conditions unrelated to cell mechanosensing or those not affected by integrin-related processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for controlling cell behavior in diseases, potentially improving treatment outcomes.
How similar studies have performed: While the specific approach of this research is innovative, similar studies have shown promise in understanding cell behavior through mechanosensing.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Bidone, Tamara — University of Utah
- Study coordinator: Bidone, Tamara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.