How cells sense and respond to mechanical forces
Official title: Molecular Mechanisms of Cytoskeletal Mechanosensory Systems
Funded at Johns Hopkins University · NIH-11018613 · Data updated 2026-11-12
This study looks at how tiny cells, like those in our bodies, use physical forces to decide how they grow, move, and divide, using a simple organism called Dictyostelium to learn more about the proteins that help them respond to these forces, which could help us understand how cells work together in different parts of our bodies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | April 1, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $543,509 |
| NIH project number | 5R01GM149073-03 |
| Project ID | NIH-11018613 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve abnormal cell behavior, such as cancer or tissue repair issues.
✕Less likely to help
Patients with stable, non-progressive conditions that do not involve cellular movement or growth may not benefit from this research.
What this research studies
This research investigates how cells use mechanical forces to guide their behaviors such as division, movement, and growth. By studying a model organism, Dictyostelium, the researchers explore the molecular machinery involved in these processes, particularly focusing on actin and myosin proteins that respond to mechanical signals. The study employs advanced modeling techniques to understand how these cellular components work together to adapt to different mechanical environments. The findings could provide insights into how cells communicate and function in various tissues.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to cell movement and growth, such as cancer.
How similar studies have gone: Previous research has shown success in understanding cellular responses to mechanical forces, making this approach promising and relevant.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Robinson, Douglas N — Johns Hopkins University
- Study coordinator: Robinson, Douglas N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.