How Cells Respond to Stress Signals
Intracellular Stress Inputs to SAPK Signaling Pathways
This research helps us understand how cells react to different kinds of stress, which is important for conditions like Alzheimer's disease and cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11088715 on NIH RePORTER |
What this research studies
Our cells constantly face various stresses, such as DNA damage, heat, or chemical toxins. This project looks at special pathways, called SAPK pathways, that cells use to respond to these challenges. We are using baker's yeast as a model to discover how different stresses activate these pathways from inside the cell, rather than from the outside. We also want to learn how cells create specific responses to each type of stress once these pathways are turned on. By studying these fundamental processes in yeast, we hope to gain insights into how human cells manage stress.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation but aims to benefit individuals with conditions like Alzheimer's disease and cancer in the future.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science project.
Why it matters
Potential benefit: Understanding how cells respond to stress could lead to new ways to develop treatments for diseases like Alzheimer's and various cancers.
How similar studies have performed: This project builds on existing evidence and ongoing work to characterize stress-response pathways in yeast.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Levin, David E. — Boston University Medical Campus
- Study coordinator: Levin, David E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.