How cells respond to stress and its impact on cancer and aging
Regulation of the Translational Response to Cellular Stress
['FUNDING_R01'] · UNIVERSITY OF GEORGIA · NIH-10794991
This study is looking at how our cells adjust their gene activity when they're under stress, like when they don't have enough nutrients or are dealing with damage, and it focuses on a specific protein that helps with this process; the goal is to learn more about how these changes can affect diseases like cancer and aging, which could help us find better ways to treat them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF GEORGIA (nih funded) |
| Locations | 1 site (ATHENS, UNITED STATES) |
| Trial ID | NIH-10794991 on ClinicalTrials.gov |
What this research studies
This research investigates how cells regulate gene expression in response to stress, such as nutrient deprivation or oxidative stress. It focuses on the translation process of mRNA, which is crucial for cell survival and function. By studying the role of a specific RNA helicase, Ded1, and its human counterpart DDX3, the research aims to understand how these mechanisms are altered in diseases like cancer and during aging. The findings could provide insights into how to better manage these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with certain types of cancer or those experiencing age-related health issues.
Not a fit: Patients with stable, non-cancerous conditions or those not affected by aging-related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers and age-related diseases by targeting the cellular stress response.
How similar studies have performed: Previous research has shown that understanding cellular stress responses can lead to significant advancements in cancer treatment, indicating a promising avenue for this investigation.
Where this research is happening
ATHENS, UNITED STATES
- UNIVERSITY OF GEORGIA — ATHENS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOLGER, TIMOTHY A — UNIVERSITY OF GEORGIA
- Study coordinator: BOLGER, TIMOTHY A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer