How cells respond to signals from their environment
Official title: Regulation of Cellular Behavior in Response to Extracellular Cues
Funded at University of Maine Orono · NIH-11080311 · Data updated 2026-11-12
This study is looking at how muscle cells react to different signals around them, which could help us learn more about muscle health and diseases, and it's being done by a team of early career scientists using tiny fish and yeast to explore these important processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maine Orono NIH-funded |
| Lab location | 1 site (Orono, United States) |
| Project start | April 5, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $2,166,759 |
| NIH project number | 5P20GM144265-03 |
| Project ID | NIH-11080311 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing muscle degeneration or related aging disorders.
✕Less likely to help
Patients with acute injuries unrelated to aging or muscle degeneration may not benefit from this research.
What this research studies
This research investigates how cells interpret and respond to various signals from their surroundings, focusing on muscle cells and their behaviors such as migration and regeneration. It involves multiple projects led by early career scientists that explore the mechanisms of cell signaling, including how viruses can alter cell functions. The research utilizes model organisms like zebrafish and yeast to understand these processes better. By examining these cellular responses, the research aims to uncover new insights into muscle health and disease.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for aging-related muscle diseases and enhance muscle regeneration.
How similar studies have gone: Other research has shown promising results in understanding cell signaling and its implications for muscle health, indicating that this approach has potential for success.
Where this research is happening
-
University of Maine Orono
Orono, United States Active
Researchers
- Principal investigator: Henry, Clarissa a — University of Maine Orono
- Study coordinator: Henry, Clarissa a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.