How cells respond to mechanical signals in their environment
Cellular mechanotransduction - from the immune response to transcriptional regulation
['FUNDING_OTHER'] · UNIV OF MARYLAND, COLLEGE PARK · NIH-10912670
This study is looking at how immune cells, like T cells, react to the physical characteristics of their environment, which could help us understand how these cells work in different health conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MARYLAND, COLLEGE PARK (nih funded) |
| Locations | 1 site (COLLEGE PARK, UNITED STATES) |
| Trial ID | NIH-10912670 on ClinicalTrials.gov |
What this research studies
This research investigates how cells, particularly immune cells like T cells, sense and respond to the mechanical properties of their surroundings. By examining the interactions between cells and their microenvironment, the study aims to uncover the molecular mechanisms that drive these responses. Using advanced imaging techniques and mathematical modeling, researchers will analyze how mechanical forces influence cell behavior and gene expression. This work could lead to a better understanding of immune responses and cellular functions in various health conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with immune-related conditions or those undergoing treatment for cancers, particularly breast cancer.
Not a fit: Patients with non-immune related conditions or those not involved in cancer treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune responses and lead to improved therapies for conditions like cancer.
How similar studies have performed: Other research has shown promising results in understanding cellular responses to mechanical signals, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
COLLEGE PARK, UNITED STATES
- UNIV OF MARYLAND, COLLEGE PARK — COLLEGE PARK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: UPADHYAYA, ARPITA — UNIV OF MARYLAND, COLLEGE PARK
- Study coordinator: UPADHYAYA, ARPITA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer