How cells respond to lack of nutrients and adapt over time
Official title: Regulated and evolutionary responses to nutritional stress
Funded at New York University · NIH-11064043 · Data updated 2026-11-12
This study is looking at how cells go into a resting state when they don't have enough nutrients, and it aims to understand the changes that happen inside the cells during this time, which could help us learn more about how cells cope with stress and relate to different diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $605,067 |
| NIH project number | 5R35GM153419-02 |
| Project ID | NIH-11064043 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to fungal infections or those who may benefit from enhanced understanding of cellular stress responses.
✕Less likely to help
Patients with conditions unrelated to cellular stress or fungal infections may not receive direct benefits from this research.
What this research studies
This research investigates how cells enter and maintain a dormant state when faced with nutritional stress, focusing on the changes in protein expression and cellular biology during this process. By using advanced techniques like metabolic labeling and mass spectrometry, the study aims to understand the genetic factors that influence cell behavior in nutrient-deprived conditions. Additionally, the research will explore how cellular environments change during quiescence using innovative imaging methods. The findings could provide insights into how cells adapt and survive under stress, which is crucial for understanding various diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving treatments for fungal infections and other conditions related to cellular stress responses.
How similar studies have gone: Previous research has shown promising results in understanding cellular responses to stress, indicating that this approach has potential for significant findings.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Gresham, David — New York University
- Study coordinator: Gresham, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.