How cells respond to changes in their genetic material
Cellular Response to Genetic Change
This study looks at how tiny worms called Caenorhabditis elegans adapt when their genes change, helping us understand how cells tell the difference between their own DNA and foreign DNA, which could be useful for anyone interested in genetics and how living things cope with changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10995341 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells and organisms adapt to changes in their genetic material. Using the model organism Caenorhabditis elegans, the study explores how cells differentiate between their own genetic information and foreign genetic material, as well as how they respond to unwanted genetic changes. The research employs various genetic and epigenetic manipulation techniques to analyze gene expression and cellular responses during developmental transitions and environmental shifts. By understanding these processes, the research aims to uncover fundamental principles of cellular adaptation and resilience.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or those interested in the mechanisms of gene expression and cellular adaptation.
Not a fit: Patients with stable genetic conditions that do not involve significant genetic changes may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to advancements in understanding genetic disorders and developing therapies that enhance cellular responses to genetic changes.
How similar studies have performed: Other research has shown success in using C. elegans as a model for studying genetic responses, indicating that this approach is well-established and promising.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Fire, Andrew Z. — Stanford University
- Study coordinator: Fire, Andrew Z.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.