How cells repair DNA damage during gene transcription
Mechanism of Transcription-coupled DNA Repair and its Impact on Cancer Mutations
This study is looking at how cells fix DNA damage that happens when they make genes, focusing on a special protein called CSB, and it aims to help us understand how these repair processes can prevent cancer-causing mutations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-11247216 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells repair DNA damage that occurs during the process of gene transcription. It focuses on the role of the Cockayne Syndrome B (CSB) protein in facilitating the repair of stalled RNA polymerase II, which can be blocked by DNA damage. By employing advanced sequencing techniques, the study aims to map different types of DNA lesions and understand how they are repaired, particularly in relation to cancer mutations. This could provide insights into how cells prevent harmful mutations that can lead to cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a predisposition to cancer or those with genetic conditions affecting DNA repair mechanisms.
Not a fit: Patients with no known issues related to DNA repair or cancer risk may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of DNA repair mechanisms, potentially informing new strategies for cancer prevention and treatment.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms, but this specific approach to mapping DNA lesions in the context of transcription is relatively novel.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Mao, Peng — State University New York Stony Brook
- Study coordinator: Mao, Peng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.