How cells repair and remove damaged lysosomes
Lysosomal membrane dynamics during stress
Researchers are learning how cells fix or clear damaged lysosomes to help people with conditions like Parkinson's disease and certain storage or immune disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11269184 on NIH RePORTER |
What this research studies
If you or a loved one has a disease linked to damaged lysosomes, this work looks at how cells respond when lysosome membranes break. The team uses powerful protein-mapping (unbiased proteomics) and high-resolution microscopy to watch what proteins go to damaged lysosomes and how those lysosomes are handled. They have discovered a new process called LYTL that involves the LRRK2 protein, which is already linked to Parkinson's and some immune conditions. The goal is to map these pathways so new treatments can target the repair or removal of damaged lysosomes.
Who could benefit from this research
Good fit: People with Parkinson's disease (especially those with LRRK2 mutations), patients with lysosomal storage disorders, or individuals with related immune conditions would be most relevant to this work.
Not a fit: Patients with conditions unrelated to lysosomal dysfunction or LRRK2 biology are unlikely to benefit directly from this specific research.
Why it matters
Potential benefit: This could identify new targets to prevent cell death and slow or stop disease processes in Parkinson's, lysosomal storage disorders, and related immune diseases.
How similar studies have performed: Research on LRRK2 and lysosomal quality control has produced promising cell and animal findings, but the LYTL pathway is a newly described process and remains early-stage.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Bonet-Ponce, Luis — Ohio State University
- Study coordinator: Bonet-Ponce, Luis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.