How cells reorganize to shape developing tissues
Regulation of dynamic actin networks during epithelial morphogenesis
['FUNDING_OTHER'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11317221
Researchers are using tiny roundworms to learn how cell scaffolding helps tissues form correctly during embryo development, which could inform understanding of some birth defects and cancers.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11317221 on ClinicalTrials.gov |
What this research studies
The team studies the roundworm C. elegans to watch how epithelial cells remodel their internal actin scaffolding as tissues change shape. They combine live imaging of embryos, single-molecule biophysics, genetic experiments, and detailed structural analysis to see how proteins at cell junctions respond to force. The project focuses on how α-catenin and related proteins sense tension and how networks of actin heal and rebuild under stress. By linking molecular behavior to whole-embryo movements, the researchers aim to reveal basic mechanisms that guide correct tissue formation.
Who could benefit from this research
Good fit: People affected by developmental birth defects or epithelial cancers are the most likely to be interested in the long-term findings and any future clinical work that builds on this research.
Not a fit: Patients with conditions unrelated to epithelial tissue remodeling (for example many purely neurological or metabolic disorders) are unlikely to see direct benefits from this basic worm-based research.
Why it matters
Potential benefit: If successful, this work could reveal cellular mechanisms that prevent or correct tissue-shaping errors and guide future approaches to prevent or treat some birth defects and epithelial cancers.
How similar studies have performed: Previous basic and animal studies have linked cadherin–catenin interactions and actin dynamics to tissue shaping, but the specific tension-sensing and actin self-healing mechanisms targeted here are still being clarified.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HARDIN, JEFFREY D — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: HARDIN, JEFFREY D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.