How cells remember their identity during cell division
The role of cis-regulatory elements in the inheritance of transcriptional memory through mitosis.
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF PENNSYLVANIA · NIH-10895965
This study is looking at how cells keep their unique roles when they divide, focusing on certain DNA parts that help control how genes work, which could help us understand important processes in early development and how cells decide what they will become.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10895965 on ClinicalTrials.gov |
What this research studies
This research investigates how cells maintain their identity through cell division by focusing on specific DNA elements that regulate gene expression. It aims to understand the role of cis-regulatory elements and trans-acting factors in preserving transcriptional programs during mitosis. By examining how these elements interact with gene promoters and enhancers, the research seeks to uncover the mechanisms that allow cells to re-establish their functions after division. This work could provide insights into early development and how cells make fate decisions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cell identity and differentiation, such as certain cancers or developmental disorders.
Not a fit: Patients with conditions unrelated to cellular transcriptional memory or identity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to advancements in understanding developmental processes and diseases related to cell identity and differentiation.
How similar studies have performed: Previous studies have shown promising results in understanding transcriptional processes during mitosis, indicating that this research builds on established findings.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OPRESCU, STEPHANIE NICOLE — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: OPRESCU, STEPHANIE NICOLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.