How cells regulate lipid levels in the body
Multimodal regulation of intracellular lipid surveillance
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11131007
This study looks at how our cells keep track of fat levels and adjust their behavior to stay healthy, focusing on a special protein that helps control this process, which could help us find better ways to manage conditions related to metabolism.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11131007 on ClinicalTrials.gov |
What this research studies
This research investigates how cells manage lipid levels, which are essential for maintaining health and energy balance. It focuses on the mechanisms by which cells sense lipid depletion and respond by adjusting the expression of genes related to lipid absorption and breakdown. By studying the role of a specific nuclear hormone receptor, NHR-49, and its interactions with other molecules, the research aims to uncover the details of how lipid signaling is regulated at the cellular level. This understanding could lead to new insights into metabolic disorders and how to better manage them.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with metabolic disorders or conditions related to lipid metabolism.
Not a fit: Patients who do not have any metabolic disorders or lipid-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing metabolic disorders related to lipid imbalances.
How similar studies have performed: Previous research has shown promising results in understanding lipid signaling mechanisms, indicating that this approach has potential for success.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DOUGLAS, PETER MAHAN — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: DOUGLAS, PETER MAHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.