How cells regulate lipid levels in the body
Official title: Multimodal regulation of intracellular lipid surveillance
Funded at Ut Southwestern Medical Center · NIH-11131007 · Data updated 2026-11-12
This study looks at how our cells keep track of fat levels and adjust their behavior to stay healthy, focusing on a special protein that helps control this process, which could help us find better ways to manage conditions related to metabolism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | July 5, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $376,962 |
| NIH project number | 5R01GM153859-02 |
| Project ID | NIH-11131007 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with metabolic disorders or conditions related to lipid metabolism.
✕Less likely to help
Patients who do not have any metabolic disorders or lipid-related health issues may not benefit from this research.
What this research studies
This research investigates how cells manage lipid levels, which are essential for maintaining health and energy balance. It focuses on the mechanisms by which cells sense lipid depletion and respond by adjusting the expression of genes related to lipid absorption and breakdown. By studying the role of a specific nuclear hormone receptor, NHR-49, and its interactions with other molecules, the research aims to uncover the details of how lipid signaling is regulated at the cellular level. This understanding could lead to new insights into metabolic disorders and how to better manage them.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing metabolic disorders related to lipid imbalances.
How similar studies have gone: Previous research has shown promising results in understanding lipid signaling mechanisms, indicating that this approach has potential for success.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Douglas, Peter Mahan — Ut Southwestern Medical Center
- Study coordinator: Douglas, Peter Mahan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.