How cells react when lysosomes are damaged
Cellular Mechanisms of Lysosomal Damage Response
This project looks at how cells respond to lysosome damage to help people with cancer, infections, and neurodegenerative diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project ID | NIH-11137737 on NIH RePORTER |
What this research studies
From a patient's perspective, the researchers will analyze the molecular signals that occur when lysosomes are damaged and how that damage triggers the formation of stress granules, which are cell structures that form under stress. They will use lab-grown cells, biochemical methods, and imaging to map the pathways and proteins involved. The work builds on recent findings that link lysosomal damage to stress granule formation and aims to clarify whether these granules protect cells or contribute to disease processes.
Who could benefit from this research
Good fit: This is laboratory-focused research that does not currently enroll patients, though people with cancer, infectious diseases, or neurodegenerative disorders could be future contributors of tissue samples or participants in follow-up studies.
Not a fit: Healthy people or those with conditions unrelated to lysosomal dysfunction are unlikely to receive direct benefits from this basic science project.
Why it matters
Potential benefit: If successful, the findings could reveal new targets to protect cells or to guide therapies for cancer and neurodegenerative diseases.
How similar studies have performed: Prior lab studies, including the PI's recent publication, provided initial evidence that lysosomal damage induces stress granules, but applying this knowledge to treatments remains largely untested.
Where this research is happening
Albuquerque, United States
- University of New Mexico Health Scis Ctr — Albuquerque, United States (Active)
Researchers
- Principal investigator: Cassano, Jingyue Jia — University of New Mexico Health Scis Ctr
- Study coordinator: Cassano, Jingyue Jia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.