How cells process genetic messages and its regulation
Mechanisms of messenger RNA splicing and RNA processing regulation
This research explores the fundamental ways our cells process genetic instructions, which is important for understanding diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11109652 on NIH RePORTER |
What this research studies
Our cells rely on a complex process called messenger RNA splicing to correctly read genetic information. This project aims to understand how the cell's machinery, called the spliceosome, assembles and works within the cell, especially as new genetic messages are being created. We want to discover how the cell's structure influences this process and how keeping certain genetic segments (introns) can regulate genes. Ultimately, we seek to understand how errors in this process can lead to cell damage and disease.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation, but future clinical applications may benefit patients with conditions linked to genetic message processing, such as certain cancers.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not receive benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how diseases like cancer develop, potentially opening doors for new ways to prevent or treat them.
How similar studies have performed: Our current understanding of genetic message processing has advanced significantly, and this work builds upon strong existing data to address remaining complex questions.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Johnson, Tracy L — University of California Los Angeles
- Study coordinator: Johnson, Tracy L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.