How Cells Pass Down Genetic Information
Mechanism of Epigenetic Inheritance
This research helps us understand how our cells accurately copy and share their genetic instructions when they divide.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11140458 on NIH RePORTER |
What this research studies
This project aims to uncover the fundamental ways our cells pass on genetic information when they divide. Our DNA is carefully packaged into structures called chromatin, which also carries important "epigenetic" instructions that tell genes when to turn on or off. A key mystery is how these epigenetic instructions are faithfully copied and transferred to new cells. Researchers are developing new tools to track how the original genetic packaging is shared with newly formed DNA, using models like yeast and mouse stem cells. This work will shed light on the very first steps of how cells maintain their identity and function across generations.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage.
Not a fit: Patients seeking immediate treatment options or direct clinical interventions would not find direct benefit from this basic science project.
Why it matters
Potential benefit: Understanding these basic cellular processes could eventually help us understand and address diseases linked to errors in genetic inheritance, such as cancer or developmental disorders.
How similar studies have performed: Researchers have made significant contributions to understanding nucleosome formation, but the specific mechanism of parental histone transfer remains largely unknown, making this a novel approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Zhang, Zhiguo — Columbia University Health Sciences
- Study coordinator: Zhang, Zhiguo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.