How cells organize their microtubules during differentiation
Official title: Mechanisms controlling microtubule organization during cell differentiation
Funded at Stanford University · NIH-11051255 · Data updated 2026-11-12
This study is looking at how cells arrange tiny structures called microtubules, which are important for their health and growth, especially in different types of cells like those in our skin and brain, to help us understand what goes wrong when these processes don't work right, potentially leading to problems like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $592,896 |
| NIH project number | 5R35GM153310-02 |
| Project ID | NIH-11051255 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by cancers or developmental disorders related to cell differentiation.
✕Less likely to help
Patients with conditions unrelated to cell differentiation or microtubule organization may not benefit from this research.
What this research studies
This research investigates the mechanisms by which cells organize their microtubules, which are essential for proper cell function and differentiation. The study focuses on non-centrosomal microtubule organizing centers (ncMTOCs) that form in various cell types, including epithelial cells and neurons, during differentiation. Using the model organism C. elegans, the research aims to uncover how these ncMTOCs are established and how their dysfunction can lead to issues such as cancer. By understanding these processes, the research hopes to provide insights into cellular behavior and development.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers and developmental disorders linked to microtubule organization.
How similar studies have gone: Previous research has shown promising results in understanding microtubule organization, but this specific focus on non-centrosomal microtubules during differentiation is relatively novel.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Feldman, Jessica Lynn — Stanford University
- Study coordinator: Feldman, Jessica Lynn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.