How cells move through 3D environments
Physical mechanisms of 3D cell motility
This study looks at how cells move through the supportive structures around them, which is important for healing wounds and understanding cancer spread, and it aims to find ways to help control this movement for better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10468934 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells navigate through three-dimensional extracellular matrices, which are crucial for processes like wound healing and cancer spread. By examining how the structure of these matrices influences cell movement, the study aims to uncover the physical principles that govern cell migration. The research focuses on the role of actomyosin contractility and how it interacts with the nucleus during this process. Ultimately, the goal is to develop therapies that can control cell migration in various medical conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to impaired wound healing or cancer.
Not a fit: Patients with conditions unrelated to cell migration or those who do not have issues with wound healing or cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve wound healing and prevent cancer metastasis.
How similar studies have performed: Previous research has shown promising results in understanding cell migration in simpler environments, but this approach to 3D matrices is relatively novel.
Where this research is happening
Philadelphia, United States
- Drexel University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Petrie, Ryan — Drexel University
- Study coordinator: Petrie, Ryan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.