How cells move and migrate during development
Regulation of directed neuroblast migration by the ECM and MAB-5/Hox
This study looks at how special cells called neuroblasts, which eventually become neurons, move to the right spots in a developing embryo, using tiny worms as a model to learn more about the proteins and signals that help guide them, with hopes of understanding similar processes in humans and other animals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Lawrence NIH-funded |
| Lab location | 1 site (Lawrence, United States) |
| Project ID | NIH-10689337 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that guide the migration of neuroblasts, which are precursor cells that develop into neurons, during embryonic development. It focuses on the role of specific proteins and signaling pathways that influence how these cells move to their designated locations in the body. By studying the model organism C. elegans, the research aims to understand the genetic and environmental factors that direct cell movement and division. This knowledge could provide insights into how similar processes occur in humans and other animals.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic conditions affecting cell migration or development.
Not a fit: Patients with conditions unrelated to cell migration or those who are not affected by developmental disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to advancements in understanding developmental disorders and conditions related to cell migration.
How similar studies have performed: Other research has shown success in understanding cell migration through similar genetic and signaling pathway approaches, indicating that this area of study is both relevant and promising.
Where this research is happening
Lawrence, United States
- University of Kansas Lawrence — Lawrence, United States (Active)
Researchers
- Principal investigator: Lundquist, Erik a — University of Kansas Lawrence
- Study coordinator: Lundquist, Erik a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.