How Cells Move and Manage Proteins
Protein Transport Across Membranes
['FUNDING_R01'] · HARVARD MEDICAL SCHOOL · NIH-11093508
This project aims to understand the basic ways our cells transport proteins and deal with those that are misfolded, which is vital for our health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11093508 on ClinicalTrials.gov |
What this research studies
Our cells constantly make and move proteins, and this project explores the intricate machinery that guides proteins to their correct locations and removes faulty ones. Researchers are using advanced imaging to visualize how proteins cross cell membranes, specifically focusing on how misfolded proteins are removed from a cell compartment called the endoplasmic reticulum. They are also investigating how proteins enter another cell compartment called peroxisomes. Understanding these fundamental processes is key because errors in protein handling can contribute to many diseases.
Who could benefit from this research
Good fit: This foundational laboratory research does not directly involve patient participation or recruitment at this stage.
Not a fit: Patients seeking immediate treatment or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could provide foundational knowledge about cellular processes that, when disrupted, contribute to various human diseases, potentially paving the way for new therapeutic strategies.
How similar studies have performed: This project builds upon recent breakthroughs in cryo-electron microscopy and prior experimental work, indicating a strong foundation for its approach.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAPOPORT, TOM A — HARVARD MEDICAL SCHOOL
- Study coordinator: RAPOPORT, TOM A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.