How cells manage zinc levels to stay healthy
Lysosome remodeling mediates high zinc homeostasis
This work explores how tiny compartments inside our cells, called lysosomes, store and release zinc, a vital nutrient for our health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11117026 on NIH RePORTER |
What this research studies
Zinc is incredibly important for human health, as it's used by about 10% of the proteins in our bodies. Our cells need a way to store extra zinc when there's a lot and release it when there's not enough. This project looks at how lysosomes, which are usually known for breaking down waste, also act as storage units for zinc. Researchers are discovering how these lysosomes change their structure to quickly manage zinc levels without disrupting their other important jobs.
Who could benefit from this research
Good fit: This foundational biological work does not directly involve patient participation at this stage, but future applications could benefit individuals with zinc-related health conditions.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not find direct benefit from this basic science research.
Why it matters
Potential benefit: Understanding how cells control zinc could lead to new ways to address health problems related to too much or too little zinc in the body.
How similar studies have performed: While the role of lysosomes in zinc storage is an emerging area, the general mechanisms of cellular zinc regulation are well-established, suggesting a strong foundation for this novel approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Kornfeld, Kerry — Washington University
- Study coordinator: Kornfeld, Kerry
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.