How cells manage their own programmed death
Cytoskeletal compartmentalization of apoptotic signaling
['FUNDING_R01'] · UNIVERSITY OF CONNECTICUT STORRS · NIH-11159836
This project explores how the internal structure of human cells helps control when and how cells decide to die, especially after damage.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CONNECTICUT STORRS (nih funded) |
| Locations | 1 site (STORRS-MANSFIELD, UNITED STATES) |
| Trial ID | NIH-11159836 on ClinicalTrials.gov |
What this research studies
Our cells have an internal scaffolding, called the cytoskeleton, which is crucial for many cell functions. This project looks at how this scaffolding influences programmed cell death, a natural process cells use to remove damaged or unwanted cells. We are focusing on specific proteins that help build this scaffolding and how they create special areas within the cell to manage the cell death process. Understanding these steps could help us learn more about diseases where cell death goes wrong.
Who could benefit from this research
Good fit: This foundational work is not directly recruiting patients but aims to benefit individuals with conditions related to abnormal cell death, such as cancer or degenerative disorders, in the future.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not find direct benefit from participating in this basic science project.
Why it matters
Potential benefit: Understanding how cells control their own death could lead to new ways to treat diseases like cancer, where cells don't die when they should, or neurodegenerative diseases, where too many cells die.
How similar studies have performed: While the general mechanisms of cell death are known, this specific focus on cytoskeletal compartmentalization in apoptosis is a novel area of investigation.
Where this research is happening
STORRS-MANSFIELD, UNITED STATES
- UNIVERSITY OF CONNECTICUT STORRS — STORRS-MANSFIELD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAMPELLONE, KENNETH G — UNIVERSITY OF CONNECTICUT STORRS
- Study coordinator: CAMPELLONE, KENNETH G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.