How Cells Manage Proteins During Stress
Mechanisms of Translation Regulation During Stress
This project explores how cells maintain healthy protein levels, which is important for understanding conditions like cancer and aging.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11115742 on NIH RePORTER |
What this research studies
Our cells constantly make and break down proteins, a process called proteostasis, which is vital for staying healthy. When this balance is disrupted, it can contribute to diseases like cancer, neurodegenerative conditions, and the aging process. This research aims to understand how cells control protein production and breakdown, especially when they are under stress. We believe that by understanding these fundamental mechanisms, we can discover new ways to diagnose and treat a variety of health issues.
Who could benefit from this research
Good fit: This foundational research is relevant to individuals affected by cancers, neurodegenerative diseases, or conditions related to aging and genetic protein imbalances.
Not a fit: Patients seeking immediate new treatments or direct clinical participation opportunities would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify and treat diseases linked to protein imbalance, such as certain cancers and age-related conditions.
How similar studies have performed: Other research suggests that protein production and breakdown pathways communicate, and inhibiting protein degradation can affect overall protein production, supporting the core idea of this work.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Moon, Stephanie Lynn — University of Michigan at Ann Arbor
- Study coordinator: Moon, Stephanie Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.