How cells manage protein production during stress
Official title: Regulation of protein synthesis during cellular stress
Funded at Henry M. Jackson Fdn for the Adv Mil/med · NIH-11020676 · Data updated 2026-11-12
This study looks at how our cells handle tough situations by changing the way they make proteins, focusing on a special protein complex called eIF2, which is important for starting the protein-making process; understanding this could help us learn more about how cells adapt to stress and how it relates to diseases like cancer and diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $372,880 |
| NIH project number | 1R35GM157233-01 |
| Project ID | NIH-11020676 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affected by cellular stress responses, including cancer patients and those with diabetes.
✕Less likely to help
Patients with conditions unrelated to cellular stress mechanisms may not benefit from this research.
What this research studies
This research investigates how cells respond to environmental stress by regulating protein synthesis. It focuses on a key protein complex called eIF2, which plays a crucial role in initiating the process of translating mRNA into proteins. During stress, eIF2 undergoes modifications that affect its ability to function, leading to changes in which proteins are produced. By understanding these mechanisms, the research aims to uncover how cells adapt to stress and the implications for diseases like cancer and diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to cellular stress, such as cancer and diabetes.
How similar studies have gone: Previous research has shown promising results in understanding cellular stress responses, indicating that this approach could yield significant insights.
Where this research is happening
-
Henry M. Jackson Fdn for the Adv Mil/med
Bethesda, United States Active
Researchers
- Principal investigator: Young-Baird, Sara Kathryn — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Young-Baird, Sara Kathryn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.