How cells manage energy to control genes
Homeostasis of one-carbon metabolism to support epigenetic methylation
This project explores how cells manage their energy to control gene activity, which is important for understanding conditions like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11144977 on NIH RePORTER |
What this research studies
Our bodies' cells use a process called one-carbon metabolism to create building blocks that help control how our genes work. When this process is out of balance, it can contribute to conditions like cancer and aging. This research aims to understand exactly how cells maintain this balance in different tissues and in growing cells. Scientists will use advanced techniques to measure how these energy units are produced and used to regulate gene activity. A clearer picture of this process could lead to new ways to address diseases where gene control is disrupted.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future studies building on this knowledge might seek patients with cancers or other conditions linked to gene regulation issues.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could reveal new targets for therapies that correct gene regulation imbalances in diseases like cancer.
How similar studies have performed: This project aims to fill a critical gap in understanding the fundamental mechanisms of one-carbon metabolism and epigenetic regulation, building on existing knowledge but addressing previously unanswered questions.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Mcbride, Matthew Joseph — Rutgers Biomedical and Health Sciences
- Study coordinator: Mcbride, Matthew Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.