How cells manage energy production and mitochondrial function
Metabolic Regulation of Mitochondrial Function
This study is looking at how cells manage their energy production, especially focusing on tiny structures called mitochondria, to see how they adapt to what the body needs, which could help us understand important processes like how cells move and respond to diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10909014 on NIH RePORTER |
What this research studies
This research investigates how cells monitor and adjust their energy production based on metabolic needs, focusing on the role of mitochondria in generating ATP, the energy currency of the cell. It explores the molecular pathways that regulate mitochondrial positioning and function, particularly through a process called O-GlcNAcylation, which links nutrient availability to cellular metabolism. By understanding these mechanisms, the research aims to shed light on critical cellular functions such as cell migration, tumor invasion, and immune responses, which are essential for maintaining health and responding to disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with metabolic disorders or cancers that may be influenced by mitochondrial function and energy regulation.
Not a fit: Patients with conditions unrelated to metabolic regulation or mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to energy metabolism, including various cancers and metabolic disorders.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function and its implications in various diseases, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Pekkurnaz, Gulcin — University of California, San Diego
- Study coordinator: Pekkurnaz, Gulcin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.