How cells make proteins on their internal machinery
Mechanisms of RNA localization and translational regulation on the endoplasmic reticulum
This project explores how our cells decide where to build important proteins and how they control this process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11109659 on NIH RePORTER |
What this research studies
Our cells have a special compartment called the endoplasmic reticulum (ER) where many crucial proteins are made. We used to think only certain proteins were made there, but new findings show that many other proteins are also created on the ER. This project aims to understand the hidden rules that guide which genetic instructions (mRNA) go to the ER and how they are used to build proteins. We want to discover if there are new ways the ER helps create all the proteins our body needs.
Who could benefit from this research
Good fit: This foundational biological work does not directly involve patient participation at this stage.
Not a fit: Patients seeking immediate new treatments or clinical trial opportunities will not find direct benefit from this basic science project.
Why it matters
Potential benefit: Understanding these basic cellular processes could help us learn more about diseases caused by protein problems, like certain neurological conditions or metabolic disorders.
How similar studies have performed: This project builds on recent unexpected discoveries about the ER's role in protein production, exploring new mechanisms that challenge existing models.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Nicchitta, Christopher V. — Duke University
- Study coordinator: Nicchitta, Christopher V.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.