How cells make heat and use energy to fight obesity and type 2 diabetes
Regulatory mechanisms of mitochondrial cristae biogenesis and thermogenic function
This work explores how our bodies create heat and manage energy within specialized fat cells, hoping to find new ways to help people with obesity and type 2 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11136535 on NIH RePORTER |
What this research studies
Our bodies have special fat cells, called brown and beige adipocytes, that can burn energy to produce heat, a process known as thermogenesis. This natural process helps regulate our body weight and metabolism. This project aims to understand the tiny structures within these fat cells, called mitochondria, and how they are built and function to generate heat. By uncovering these fundamental mechanisms, we hope to discover new targets for developing more effective and affordable treatments for metabolic conditions like obesity and type 2 diabetes.
Who could benefit from this research
Good fit: This foundational research focuses on mechanisms relevant to adults living with obesity and type 2 diabetes.
Not a fit: Patients seeking immediate treatment options will not directly benefit from this basic science research, as it aims to understand fundamental biological processes.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that activate the body's natural heat-producing processes to help manage obesity and type 2 diabetes.
How similar studies have performed: This project builds on the recent identification of a new mechanism controlling mitochondrial activity, suggesting a novel approach to understanding thermogenesis.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Puigserver, Pere — Dana-Farber Cancer Inst
- Study coordinator: Puigserver, Pere
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.