How cells make and send proteins that affect tissues and disease
Unraveling the mammalian secretory pathway through systems biology and algorithm development
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11123085
Creating computer and lab tools to map how cells produce and secrete proteins that matter for conditions like Alzheimer's and cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11123085 on ClinicalTrials.gov |
What this research studies
Researchers will combine large-scale lab data and computer algorithms to map the cellular machinery that makes and ships secreted and membrane proteins. They will analyze how these pathways differ across tissues and link those patterns to processes like hormone release, ER stress, and amyloid formation. The project mixes systems biology, proteomics/genomics data, and algorithm development to predict which machinery each protein depends on. Results aim to point to specific pathway changes that matter in diseases such as Alzheimer's and various cancers.
Who could benefit from this research
Good fit: People with Alzheimer's disease or certain cancers who can provide tissue, blood, or clinical data for research would be the most relevant candidates for involvement.
Not a fit: People without disorders involving secreted or membrane proteins, or those unable to provide samples or data, are unlikely to receive direct benefit from this research.
Why it matters
Potential benefit: Could reveal new biomarkers or drug targets to improve diagnosis or treatment for Alzheimer's disease and some cancers.
How similar studies have performed: Previous systems-biology and proteomics projects have mapped secreted proteins, but large-scale mapping of which cellular machinery each secreted or membrane protein requires is largely novel.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEWIS, NATHAN ENOCH — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: LEWIS, NATHAN ENOCH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Cancers