How Cells Make and Process Genetic Instructions
Cross-regulation between transcription and pre-mRNA splicing
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11086099
This project helps us understand the basic steps cells take to read our genes and prepare them for use.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11086099 on ClinicalTrials.gov |
What this research studies
Our bodies' cells constantly read genetic instructions to function properly. This process involves two key steps: making a copy of a gene (transcription) and then editing that copy to remove unnecessary parts (splicing). This project looks closely at how these two steps work together at the same time. We want to learn how cells ensure that these processes happen smoothly and correctly, especially how they decide which parts of the genetic message to keep or discard. Understanding these fundamental mechanisms is crucial for overall cell health.
Who could benefit from this research
Good fit: This foundational biological project does not involve direct patient participation.
Not a fit: Patients will not receive direct medical benefit from this basic science project.
Why it matters
Potential benefit: A deeper understanding of these fundamental cellular processes could eventually lead to new ways to address diseases caused by errors in gene expression, such as certain genetic disorders or cancers.
How similar studies have performed: The lab has previously developed new methods for studying these processes and made recent discoveries, indicating a novel approach.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NEUGEBAUER, KARLA M — YALE UNIVERSITY
- Study coordinator: NEUGEBAUER, KARLA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.