How cells maintain their shape during division
Cell-cycle-dependent cell polarity control
This study is looking at how cells get their shape back after they divide, which is really important for them to work properly, and it's using a type of yeast to explore how a specific protein helps control this process—what they learn could help us understand more about cancer and other health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston College NIH-funded |
| Lab location | 1 site (Chestnut Hill, United States) |
| Project ID | NIH-10800798 on NIH RePORTER |
What this research studies
This research investigates how cells regain their polarized shape after division, which is crucial for their proper function. Using the fission yeast model, the study focuses on the role of a protein called Cdc42 in regulating cell growth and shape during the cell cycle. By manipulating genetic tools, researchers aim to understand the cues that control cell polarity and how disruptions in this process can lead to cancer and other disorders. The findings could provide insights into the fundamental mechanisms of cell behavior and their implications for disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or metabolic disorders that may be influenced by cellular growth and division abnormalities.
Not a fit: Patients with non-malignant conditions unrelated to cell division or growth may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers and metabolic disorders linked to cell shape anomalies.
How similar studies have performed: Other research has shown success in understanding cell polarity and its implications for cancer, making this investigation a continuation of established scientific inquiry.
Where this research is happening
Chestnut Hill, United States
- Boston College — Chestnut Hill, United States (Active)
Researchers
- Principal investigator: Das, Maitreyi — Boston College
- Study coordinator: Das, Maitreyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.