How cells keep chromosomes correct when they divide
Mechanisms of Mitotic Fidelity
['FUNDING_OTHER'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11144561
This project looks at the tiny machines inside cells that make sure chromosomes split correctly, with the goal of helping people affected by aneuploidy-related birth defects and cancers.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11144561 on ClinicalTrials.gov |
What this research studies
The lab uses cell-based experiments to study the mitotic spindle and the motor proteins that move chromosomes during cell division. Researchers examine how motors are turned on and off in time and space, and how groups of motors work together to prevent mistakes. Work uses cellular models and biochemical tools to map protein interactions and dynamics that lead to accurate chromosome segregation. Findings aim to point toward molecular targets that could be useful for treating cancers or understanding causes of birth defects.
Who could benefit from this research
Good fit: This project does not enroll patients, but its findings are most relevant to people with cancers marked by abnormal chromosome numbers and families affected by aneuploidy-related birth defects.
Not a fit: People with conditions unrelated to chromosome segregation (for example, infectious diseases or metabolic disorders) are unlikely to see direct benefits from this research.
Why it matters
Potential benefit: If successful, this work could identify new molecular targets for cancer therapy and improve understanding of how aneuploidy causes birth defects.
How similar studies have performed: Prior laboratory studies have established key roles for motor proteins and spindle mechanics and some cancer drugs target cell division, but translating motor-specific findings into treatments remains an emerging area.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WALCZAK, CLAIRE E — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: WALCZAK, CLAIRE E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.