How cells get their shape and position in early development
Cell polarity and morphogenesis in Xenopus embryos
['FUNDING_OTHER'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11121070
This project explores how cells organize themselves to form body structures during early development, which is important for understanding birth defects.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11121070 on ClinicalTrials.gov |
What this research studies
Our bodies begin as a few cells that must correctly arrange themselves to form tissues and organs. This project looks at how cells decide where to go and what shape to take during these crucial early stages. We are focusing on a key communication system within cells, called the planar cell polarity (PCP) pathway, which guides these movements. Understanding these basic steps could help us learn more about how birth defects happen.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation, but future studies building on this work may benefit individuals affected by birth defects or developmental disorders.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this fundamental knowledge could provide insights into the causes of birth defects and other developmental problems.
How similar studies have performed: The core planar cell polarity pathway has been extensively studied in other model organisms, with its vertebrate homologs known to be involved in key developmental processes.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SOKOL, SERGEI — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: SOKOL, SERGEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.