How cells form protective microridges on mucosal surfaces
Mechanisms of microridge protrusion morphogenesis on mucosal epithelial cells
This study is looking at tiny structures called microridges on the surface of cells in places like your eyes and mouth, using zebrafish skin cells to learn how they form and work, which could help us understand how these structures keep our tissues safe from harm and infection.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10993183 on NIH RePORTER |
What this research studies
This research investigates the formation of microridges, which are tiny, elongated protrusions on the surface of mucosal epithelial cells, such as those found in the cornea and mouth. By using larval zebrafish skin cells as a model, the study aims to understand the molecular mechanisms behind microridge morphogenesis, including the role of actin and myosin in shaping these structures. The research employs advanced techniques like live imaging to observe these processes in real-time, potentially uncovering new insights into how these structures help protect epithelial tissues from damage and infection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that compromise mucosal integrity, such as chronic dry mouth or corneal disorders.
Not a fit: Patients with non-epithelial related conditions or those not experiencing mucosal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing mucosal protection, which may benefit patients with conditions affecting epithelial tissues.
How similar studies have performed: While the study of microridge morphogenesis is relatively novel, previous research on cellular protrusions has shown promising results in understanding cell behavior and tissue protection.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Sagasti, Alvaro — University of California Los Angeles
- Study coordinator: Sagasti, Alvaro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.