How cells fight off viruses using a special RNA system
Understanding the antiviral roles of acellular RNA quality control pathway
This project explores how a natural cell process called NMD helps our bodies defend against common viruses like Zika.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11086843 on NIH RePORTER |
What this research studies
Our cells have clever ways to keep their genetic instructions in order, including a system called Nonsense-mediated mRNA decay (NMD). While NMD usually cleans up faulty genetic messages, we're learning it also plays a key role in fighting off viral infections. This work aims to uncover how NMD proteins recognize and combat viruses, even when viruses try to shut down this defense. Understanding these cellular battles could open new doors for developing treatments against viral diseases.
Who could benefit from this research
Good fit: This foundational research is not recruiting patients directly but is relevant to anyone affected by or at risk for RNA viral infections, including alphaviruses, coronaviruses, and flaviviruses.
Not a fit: Patients seeking immediate treatment options for viral infections may not see direct benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could reveal new ways to strengthen our cells' natural defenses against a range of viral infections, potentially leading to new antiviral therapies.
How similar studies have performed: Recent studies have already indicated that components of the NMD pathway are involved in the body's defense against RNA viruses, suggesting a promising area of investigation.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Steckelberg, Anna-Lena — Columbia University Health Sciences
- Study coordinator: Steckelberg, Anna-Lena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.