How cells correctly divide to create reproductive cells
Joint Molecule Resolution During Meiotic Recombination
This project looks at how cells properly share genetic material during the process that creates eggs and sperm, which is important for healthy reproduction.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11143210 on NIH RePORTER |
What this research studies
Meiosis is a special type of cell division that produces eggs and sperm, and it requires precise genetic mixing, known as crossing over. This project aims to understand the exact molecular steps of how these genetic exchanges are completed, focusing on specific structures called double-Holliday junctions. Researchers are developing new methods to study these processes in detail, including how certain proteins guide the genetic exchange. A deeper understanding of these fundamental steps could help explain why some individuals experience difficulties with reproduction.
Who could benefit from this research
Good fit: This foundational work does not directly involve patient participation, but individuals interested in the genetic causes of infertility or reproductive health may find this research relevant.
Not a fit: Patients not experiencing issues with fertility or genetic conditions related to cell division may not find direct relevance in this specific basic science project.
Why it matters
Potential benefit: Understanding these fundamental cellular processes could eventually help explain causes of infertility or genetic problems that arise from errors in cell division.
How similar studies have performed: While the overall field of meiosis has seen progress, this project addresses a fundamental gap in understanding specific molecular steps, building on recent breakthroughs in related areas.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Hunter, Neil — University of California at Davis
- Study coordinator: Hunter, Neil
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.