How cells control which proteins they make during stress and aging
Post-transcriptional regulations of proteomes in stress and senescence
This project builds new lab methods to track how tissues change which protein versions they make when they face stress or aging.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11146580 on NIH RePORTER |
What this research studies
Researchers will combine protein and RNA measurements using mass spectrometry and multi-omics to map which protein isoforms appear in different tissues over time. They will study three post-transcriptional processes: alternative splicing, RNA-binding proteins, and the ribosome and its associated factors. The team will use models of proteostatic stress (paraquat in vivo and doxorubicin or hydrogen peroxide in cells) to see how these processes change protein localization and interactions. The goal is to produce detailed atlases of proteoforms and translation complexes that can guide future work on aging and disease.
Who could benefit from this research
Good fit: People interested in contributing tissue samples or joining future translational studies related to aging and proteostasis, typically through the University of Colorado Denver, would be the best matches.
Not a fit: Patients seeking immediate clinical treatments or those with conditions unrelated to aging or protein homeostasis are unlikely to benefit directly from this basic laboratory research.
Why it matters
Potential benefit: If successful, this work could identify molecular targets to help cells maintain healthy protein balance during aging and in age-related conditions.
How similar studies have performed: Related mass-spectrometry and multi-omics studies have mapped proteomes and splicing changes before, but combining isoform-resolved proteomics with ribosome interactome mapping is a relatively new and developing approach.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Lam, Maggie — University of Colorado Denver
- Study coordinator: Lam, Maggie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.