How cells control the breakdown of messenger RNA
Official title: Molecular Mechanisms that Control mRNA Decapping in Biological Condensates
Funded at University of California, San Francisco · NIH-11061917 · Data updated 2026-11-12
This study is looking at how certain proteins help break down messenger RNA (mRNA) in special parts of cells, which could help us understand more about how our genes work and are controlled.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $318,234 |
| NIH project number | 5R01GM148881-03 |
| Project ID | NIH-11061917 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions linked to mRNA degradation, such as certain types of cancer.
✕Less likely to help
Patients with conditions unrelated to mRNA regulation or those not diagnosed with cancer may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms that regulate the degradation of messenger RNA (mRNA) within specialized cellular structures called biological condensates. By focusing on the decapping enzyme complex, which removes a protective cap from mRNA, the study aims to understand how this process is influenced by protein interactions and phase separation within these condensates. The researchers will use advanced fluorescence probes to observe these interactions and determine the structural changes that occur in the decapping enzymes. This work could provide insights into the fundamental processes of gene expression and regulation.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to mRNA regulation, including various cancers.
How similar studies have gone: While the specific approach of this research is novel, similar studies have shown promise in understanding mRNA dynamics and their implications in cellular processes.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Gross, John D — University of California, San Francisco
- Study coordinator: Gross, John D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.